NR3C1 and chronic obstructive pulmonary disease: Conversely, other studies found similar baseline GR levels in both glucocorticoid-sensitive and glucocorticoid-resistant patients of adult asthma (73), chronic obstructive pulmonary disease (74), idiopathic nephrotic syndrome (75), and Vogt–Koyangi–Haradi syndrome (76), suggesting alternative GR-expression-independent mechanisms of glucocorticoid resistance.