The goals of this longitudinal and prospective study of healthy elderly therefore were to (1) explore the relationship of a cross-sectional and longitudinal measurement of brain aging and (2) take into account potential influencing factors of hippocampal atrophy rates, such as APOE and amyloid status, education, as well as sex and (3) investigate the association with cognitive measures. The gene discussed is APOE; the disease is hippocampal atrophy.