APOE and hippocampal atrophy: The goals of this longitudinal study of healthy elderly were to (1) explore the relationship of a cross-sectional and longitudinal measurement of brain aging, namely the association between baseline hippocampal volumes and APC in hippocampal volumes over time, and (2) take into account potential influencing factors of hippocampal atrophy rates, such as APOE and amyloid status, education, as well as sex and (3) investigate the association with cognitive measures.