IDH1 and neoplasm: In the PSM cohort, univariate Cox analysis similarly identified age (P = 0.028, HR = 1.033, 95% CI: 1.003–1.063), WHO tumor grade (P < 0.001, HR = 4.948, 95% CI: 2.638–9.281), IDH mutation status (P < 0.001, HR = 0.286, 95% CI: 0.156–0.524), TERTp mutation status (P = 0.049, HR = 0.544, 95% CI: 0.296–0.998), 1p/19q co-deletion (P = 0.023, HR = 2.249, 95% CI: 1.119–4.519), and AAPR (P = 0.025, HR = 0.526, 95% CI: 0.301–0.921) as significant prognostic factors (Figure 5C).