IDH1 and neoplasm: In the entire cohort, univariate Cox analysis identified several significant prognostic factors for LGG: age (P < 0.001, HR = 1.038, 95% CI: 1.018–1.058), WHO tumor grade (P < 0.001, HR = 4.688, 95% CI: 2.913–7.546), IDH mutation status (P < 0.001, HR = 0.315, 95% CI: 0.199–0.497), 1p/19q co-deletion (P = 0.001, HR = 2.355, 95% CI: 1.389–3.990), and AAPR (P = 0.005, HR = 0.541, 95% CI: 0.353–0.829) (Figure 5A).