GR, crucial for maintaining the pool of reduced GSH, has shown varied alterations depending on the cell type or tissue examined; studies have reported GR activity to be unvaried in erythrocytes of CF children (Carmagnol et al., 1983), while intracellular GR activity was significantly higher in lung tissue from Cftr-KO mice (Velsor et al., 2001), and conversely, significantly decreased in CF bronchial epithelial cells compared to WT controls (de Bari et al., 2018). This evidence concerns the gene CFTR and cystic fibrosis.