Glutathione peroxidases (GPxs), which utilize GSH for H2O2 detoxification, show no evident reduction in CF; in fact, elevated GPx levels have been reported in CF sputum (Dauletbaev et al., 2005) and increased extracellular GPx3 was identified in CF BALF (Kalsi et al., 2025). The gene discussed is GPX3; the disease is cystic fibrosis.