CFTR and cystic fibrosis: Intriguingly, transcriptomic analysis has not been applied only to identify differences in gene expression between cells with or without a functional CFTR (Kamei et al., 2019; Declercq et al., 2021), but also to characterize the transcriptional activity of each cell type component of the lung epithelia (Zoso et al., 2019; Sun and Zhou, 2025) and to study pathogen virulence in CF patients (Worgall et al., 2005; Drevinek et al., 2008; Rossi et al., 2018; Irvine et al., 2019).