HP and idiopathic pulmonary fibrosis: However, in Idiopathic Pulmonary Fibrosis (IPF), a chronic lung disease that shares some pathological features with CF, including fibrosis and significant oxidative stress, plasma proteomics has identified haptoglobin-related protein as a potential biomarker, being involved in antioxidant responses, alongside evidence of dysregulated oxidative pathways (Saraswat et al., 2020).