Another example of excitotoxic damage happens in the muscular endplate due to rare genetic disorders, such as congenital myasthenic syndromes (CMS; Grassi and Fucile, 2020), which involves mutations in the genes of proteins related to neuromuscular transmission, mostly (about 15%) AChE gene (Beeson et al., 2005; Engel, 2012). The gene discussed is ACHE; the disease is congenital myasthenic syndrome.