A landmark proteomic study identified six CRC-specific sEV proteins that effectively discriminate between early-stage CRC, advanced CRC, and healthy controls: glutamate-cysteine ligase modulatory subunit (GCLM), Kell blood group complex subunit (KEL), apolipoprotein F (APOF), complement factor B (CFB), phosphodiesterase 5A (PDE5A), and 5’-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) (99). The gene discussed is PDE5A; the disease is colorectal carcinoma.