To this end, we analyzed BRCA, LUAD, and ccRCC multi-omic data to demonstrate the utility of mGrades in research, revealing features not captured by pathological grading, such as EMT, SHH signaling (BRCA), proliferation and Notch signaling (LUAD), and the Warburg Effect (ccRCC). Here, SHH is linked to nonpapillary renal cell carcinoma.