Two-dimensional VisiumTM maps show concentric aggregates of M2‐TAMs and osteoclast-like mononucleated giant cells girdling necrotic bone trabeculae, while MARCOhigh macrophages preferentially align along peri-vascular tracks, often in direct apposition to SOX9+ stem-like tumour cells. This evidence concerns the gene SOX9 and neoplasm.