Lymphoid CAFs in FL provide critical signals that directly promote tumor B-cell growth and contribute to the building and function of the tumor-supportive niche, particularly through the overexpression of CCL2, CXCL12, CCL19, and CCL21 and the modification of extracellular matrix composition and organization (13, 105, 106, 109, 110) influences the tumor niche. This evidence concerns the gene CCL21 and neoplasm.