CXCL12 and neoplasm: Lymphoid CAFs in FL provide critical signals that directly promote tumor B-cell growth and contribute to the building and function of the tumor-supportive niche, particularly through the overexpression of CCL2, CXCL12, CCL19, and CCL21 and the modification of extracellular matrix composition and organization (13, 105, 106, 109, 110) influences the tumor niche.