Through differential analysis of the two groups of tumor cells, we observed a significant upregulation of metabolism-associated genes (e.g., APOE, FABP1) in the low-PCD group, whereas a diverse array of cancer-promoting genes (e.g., S100A11, LDHA) exhibited heightened expression levels in the high-PCD group (Figure 3C). This evidence concerns the gene APOE and neoplasm.