IGFBP3 and hepatocellular carcinoma: In our study, we developed a signature comprising 17 PCD-related genes (ENO1, CDK4, RPS17, PDLIM1, KLHDC10, IGFBP3, UBE2E1, CBS, UBB, YWHAQ, SPP1, USF2, STAT6, PCK2, CACYBP, HDAC1, CD79A), which demonstrated predictive capability for OS in patients with HCC.