In our study, we developed a signature comprising 17 PCD-related genes (ENO1, CDK4, RPS17, PDLIM1, KLHDC10, IGFBP3, UBE2E1, CBS, UBB, YWHAQ, SPP1, USF2, STAT6, PCK2, CACYBP, HDAC1, CD79A), which demonstrated predictive capability for OS in patients with HCC. The gene discussed is SPP1; the disease is hepatocellular carcinoma.