Transcriptomic and single-cell atlases show that high-grade gliomas over-express both tachykinin and calcitonin-family G-protein-coupled receptors (GPCRs); notably, neurokinin-1 receptor (NK1-R) and the calcitonin receptor-like receptor (CLR, encoded by CALCRL) track with mesenchymal programmes and shortened survival, underscoring their functional relevance to tumour spread (12, 48). Here, CALCRL is linked to neoplasm.