TCGA molecular subtype analysis indicated that patients with the GS subtype had a higher proportion of those exhibiting an immunosuppressive barrier, which may explain their poor prognosis (55, 56), while the MP subtype corresponded to the “ Immune Barrier Dominant” type and the EP subtype was consistent with the “ CD8+ T Cell Exhaustion Dominant” type, suggesting the potential for chemotherapy combined with immunotherapy (57). This evidence concerns the gene CD8A and hyperplastic polyp.