RGCC and Fanconi anemia: In addition to its extensively reported role in cell cycle modulation, the RNA-seq profiling revealed that suppression of RGC32 expression significantly attenuated several DNA damage response mechanisms, encompassing Fanconi anemia pathway, mismatch repair (MMR), DNA replication, homologous recombination (HRR) and nucleotide excision repair (NER) (Figure 3C).