Others report on an increase of epidermal growth factor mRNA in distal convoluted tubular epithelial cells that is known to increase TRPM6 expression acting as a magnesiotropic hormone (Fig 3).55, 56, 57, 58, 59 Of interest, the overall magnesium-sparing effect seems to be more pronounced in patients with hypomagnesemia refractory to traditional therapy, suggesting beneficial use of sodium glucose linked transporter 2-inhibitors and potential for future research. The gene discussed is TRPM6; the disease is Hypomagnesemia.