For neurodegenerative disorders with inflammatory components, a contrasting approach utilizes CAR-Tregs with CARs that target misfolded proteins associated with respective disorders, such as amyloid β (Aβ) for Alzheimer’s disease, superoxide dismutase 1 (SOD1) or Tar DNA binding protein-43 (TDP-43) for amyotrophic lateral sclerosis (ALS). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.