Dietary vitamin B12 and folate, which promotes enzymatic conversion of Hcy to methionine, decreased HHcy, and restored Stx17 and autophagy, stimulated β-oxidation of fatty acids, and improved hepatic histology in mice with pre-established MASH (114), suggesting that vitamin B12 and folate could have therapeutic potential for the prevention or treatment of MASH. This evidence concerns the gene STX17 and metabolic dysfunction-associated steatohepatitis.