Subpial lesions were previously considered unique to MS, as they had not observed in a range of other neuroinflammatory or neurodegenerative conditions[21,97,98] until the recent report describing their presence in autopsy and biopsy specimens from patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorders (MOGAD)[99]. This evidence concerns the gene MOG and myeloid sarcoma.