Indeed, continuous expression of TNFa and IFNg in the meningeal compartment of MOG-immunized DA rats, delivered via lentiviral transfer vectors, recapitulated many aspects of the relationship between meningeal inflammation, subpial demyelination, and neuronal loss (including the upregulation of necroptotic pathways) observed in the post-mortem tissue of MS patients[121]. Here, IFNG is linked to myeloid sarcoma.