MTOR and nonpapillary renal cell carcinoma: ,42 Furthermore, through pathway network analysis, we revealed that the deregulations of the ccRCC primary site associated with PFS values were rather captured by the phosphatidylinositol, ERBB, and mTOR signaling pathways and by the ascorbate and aldarate metabolism and the mismatch repair system, while those of metastases were linked to cytokine inflammation, sphingolipid metabolism, aminoacyl-tRNA biosynthesis, and citrate-tricarboxylic acid (TCA) cycle pathways, as well as the nucleotide excision process.