PIK3CA and colorectal carcinoma: In CRC, the nuclear receptor Nur77 has been recognized as a novel promoter of hypoxia‐induced metastasis by controlling miRNA biogenesis through the suppression of Dicer via p63 suppression, which subsequently increases PI3K subunit p110α stability and stimulates AKT/β‐catenin, thereby facilitating EMT and cancer stemness [257, 258, 259, 260].