Conversely, FAT atypical cahderin 4 (FAT4) can impair CRC by decreasing proliferation, migration, and EMT while enhancing autophagy; its functions are partially triggered through the downregulation of the PI3K/AKT pathway, highlighting the roles of both mTOR and GSK‐3β [67, 68, 69]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.