Cytokines produced from TAMs (CXCL5) and substances released by CAFs (SLPI, IGF2, IL‐8) stimulate the PI3K/AKT pathway, accelerating carcinogenesis, metastasis, angiogenesis, and chemoresistance in several tumors, including GC, OC, and CRC. This evidence concerns the gene AKT1 and colorectal carcinoma.