Natural compounds such as wogonin, CA, Huaier, and isorhamnetin have demonstrated efficacy in overcoming hypoxia‐induced drug resistance or suppressing EMT and carcinogenesis by affecting PI3K/AKT/HIF‐1α, consequently reducing glycolysis, angiogenesis, and metastatic potential in cancers. The gene discussed is PIK3CG; the disease is cancer.