Molecular factors such as PTPRH, CPNE1, APLN, PLOD1, SPAG4, B7‐H3, and SIK2 have been shown to facilitate carcinogenesis and glycolysis via PI3K/AKT induction, whereas inhibitors of this pathway reduce glycolytic flux, diminish tumor growth, and increase sensitivity to anticancer drugs. The gene discussed is SIK2; the disease is neoplasm.