IL6 and cardiovascular disorder: Crucially, excessive and dysregulated IL-6 production is a risk factor for various diseases and disorders (e.g., cardiovascular disease) and often correlates with symptom severity (including pain intensity and declines in physical and cognitive function) (Sharma and Singh, 2014; Singh and Newman, 2011; Carp et al., 2008; Klyne et al., 2017).