Baseline CD4 count < 200 (AOR 6.1, 95%CI 2.06, 18.43), clients infected with TB (AOR 4.8 95%CI 1.78, 12.96), treatment interruption (AOR 3.05, 95% CI 1.06, 8.77), and adherence (AOR 3.67, 95%CI 1.39, 9.66) were statistically significant association. The gene discussed is CD4; the disease is tuberculosis.