A PPI network of the intersecting genes between fucoidan and liver cancer was established, revealing that targets such as HSP90AA1, JUN, PTPRC, MMP9, DPP4, TLR4, STAT3, AR, CASP3, and KDR ranked significantly high, providing important clues for further exploration of the potential mechanisms by which fucoidan regulates liver cancer. The gene discussed is STAT3; the disease is liver cancer.