In summary, this study integrated network pharmacology and molecular docking analysis to identify potential targets, and elucidate the underline mechanism of fucoidan in the treatment of liver cancerUltimately, in vitro cellular experiments confirmed its suppressive impact on the viability of liver cancer cells and its ability to induce apoptosis in these cells, suggesting that the anticancer mechanism of fucoidan could possibly be associated with the downregulation of the pathway of PI3K/Akt signaling. Here, PIK3CA is linked to liver cancer.