A PPI network of the intersecting genes between fucoidan and liver cancer was established, revealing that targets such as HSP90AA1, JUN, PTPRC, MMP9, DPP4, TLR4, STAT3, AR, CASP3, and KDR ranked significantly high, providing important clues for further exploration of the potential mechanisms by which fucoidan regulates liver cancer. Here, HSP90AA1 is linked to liver cancer.