A PPI network of the intersecting genes between fucoidan and liver cancer was established, revealing that targets such as HSP90AA1, JUN, PTPRC, MMP9, DPP4, TLR4, STAT3, AR, CASP3, and KDR ranked significantly high, providing important clues for further exploration of the potential mechanisms by which fucoidan regulates liver cancer. This evidence concerns the gene CASP3 and liver cancer.