A study based on multiple European cohort datasets found that among men carrying the APOE ε2/ε3 heterozygous genotype, those with both the APOE ε2/ε3 genotype and the rs440446 heterozygous (CG) variant exhibited significantly enhanced protection against AD compared to those carrying the rs440446 GG variant (Kulminski et al., 2021). The gene discussed is APOE; the disease is Alzheimer disease.