NRG1 and Familial prostate cancer: Although Zhang et al. have identified that CAFs are a possible source of paracrine sNRG1, data from The Cancer Genome Atlas (TCGA) dataset 46 suggest that other potential sources of NRG1 could include prostate cancer cells, benign genitourinary tract cells, immune cells, and neuroendocrine cells, whether it is autocrine, paracrine, or endocrine remained unclear.