AKT1 and lung cancer: Reports suggest that CBX3 has been identified as a key player in lung cancer progression by interacting with pathways such as phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT), rat sarcoma virus (Ras)/ kirsten rat sarcoma virus (KRAS), Wnt/β-catenin, mitogen-activated protein kinase (MAPK), Notch, and p53, leading to increased proliferation and therapy resistance 7.