It promotes tumor proliferation by upregulating phosphoglycerate dehydrogenase (PHGDH) expression via interaction with the histone acetyltransferase general control non-depressible 5 (GCN5), enhancing serine biosynthesis; concurrently, it suppresses metastasis by repressing zinc finger E-box binding homeobox 2 (ZEB2) transcription through PRC1-mediated H2AK119 ubiquitination 23. Here, PHGDH is linked to neoplasm.