Furthermore, CYP2S1 knockout promoted the nuclear translocation of β-catenin in intestinal epithelial cells of APCMin/+ mice and in cancer cells, it also activated Wnt and modulated P53 signaling pathways, upregulating metastasis associated in colon cancer 1 (MACC1), which accelerated cancer cell proliferation and invasion. The gene discussed is CYP2S1; the disease is cancer.