KCNA3 and neoplasm: To compare the prognostic efficacy of our A2M-based nomogram model (C-index = 0.786) with existing ccRCC models, we integrated previous studies that utilized features with distinct biological significance, such as metabolism (C-index = 0.774) 49, cuproptosis (C-index = 0.77) 50, ferroptosis (C-index = 0.771) 51, glycolysis (C-index = 0.781) 52, m6A and m5C (C-index = 0.737) 53, potassium channels (C-index = 0.76) 54, tumor microenvironment (C-index = 0.744) 55, and immune features (C-index = 0.786) 56.