In the fifth edition of the classification of urogenital tumors published by WHO in 2022, in addition to the morphologically based classification, rare RCC categories defined by molecules (such as Fumarate hydratase-deficient RCC, Succinate dehydrogenase-deficient RCC, SMARCB1-deficient RCC, and ALK-rearranged RCC) has been added 4. Here, ALK is linked to renal cell carcinoma.