For example, baicalein (Wang et al., 2021), rutin (Aruna et al., 2014), naringenin (Li Y. et al., 2018), and luteolin (Rajapriya and Geetha, 2021) have been shown to inhibit the assembly of NLRP3 inflammasome complexes, thereby reducing caspase-1 activation and subsequent IL-1β maturation in AP models. This evidence concerns the gene CASP1 and alkaline phosphatase measurement.