The subsequent intersection of 26 common upregulated DEGs, 118 common downregulated DEGs, and 1,797 ISR-RGs yielded eight candidate genes related to integrated stress response in AMD (Figure 2A): RIC3, GRIN1, AKAP6, SGPP2, STOX1, SLFN11, FAM111A, and PKD2. Here, SGPP2 is linked to age-related macular degeneration.