GRIN1 and autism spectrum disorder: Pathogenic GRIN1 variants cause intellectual disability (100% of patients), muscular hypotonia (66% of patients), epilepsy (65% of patients), motor dysfunction (48% of patients), cortical visual impairment (CVI; 34% of patients), autism spectrum disorder (ASD; 22% of patients), and sleep problems (15% of patients) (Benke et al., 2021).