BCI compromise the safetyof medical instruments and materials that are frequently essentialto the proper function of individual organs or the entire organism. Equally concerning is the formation of thrombi,resulting from the adsorption of fibrinogen and von Willebrand factor(vWF) on materials used in the treatment of cardiovascular diseases.These thrombi pose serious, life-threatening risks to patients. Given these challenges, there is an urgent needto develop functional coatings that effectively prevent the adhesionof biological entities to materials intended for medical applications. Here, VWF is linked to cardiovascular disorder.