CTFs can interact with synaptotagmin 7 (Syt7) in presynaptic terminals leading to impaired synaptic facilitation and replenishment of synaptic vesicles.61 This interaction at presynaptic terminals might be of particular interest in the context of presynaptic failure in AD models, where CTFs are overexpressed alongside other APP fragments.62 The gene discussed is SYT7; the disease is Alzheimer disease.