It has been widely recognized that AS patients also show cognitive decline and have higher risk of dementia like Alzheimer's disease (AD) [4], the most common form of dementia in the elderly, which exhibits typical neuropathological features of amyloid‐β (Aβ) deposits, neurofibrillary tangles composed of hyperphosphorylated tau protein, and neuroinflammation [5]. Here, MAPT is linked to Alzheimer disease.