APOE and memory impairment: Similarly, in the learning phase of the MWM test, APOE4‐HFD mice had a much higher escape latency on day 5 than that of APOE3‐HFD mice, while in the test phase, APOE4‐HFD mice spent much less time in the target quadrant than APOE3‐HFD mice, indicating more exacerbated learning and memory impairments of APOE4 AS mice (Figure 3H,I).