The objectives of the present study were: (1) evaluating oxidative stress markers (8‐hydroxy‐2′‐deoxyguanosine; 8‐OHdG and oxidized LDL; Ox‐LDL) and intercellular adhesion molecules (ICAM‐1 and E‐selectin) as early endothelial dysfunction markers in normoglycemic offspring of patients with T2DM, (2) investigating the possible relationship between these biomarkers, and (3) comparing these markers across different glucose tolerance statuses (IFG and IGT). This evidence concerns the gene SELE and type 2 diabetes mellitus.