The objectives of the present study were: (1) evaluating oxidative stress markers (8‐hydroxy‐2′‐deoxyguanosine; 8‐OHdG and oxidized LDL; Ox‐LDL) and intercellular adhesion molecules (ICAM‐1 and E‐selectin) as early endothelial dysfunction markers in normoglycemic offspring of patients with T2DM, (2) investigating the possible relationship between these biomarkers, and (3) comparing these markers across different glucose tolerance statuses (IFG and IGT). The gene discussed is ICAM1; the disease is type 2 diabetes mellitus.