Under hyperglycemia, inflammatory mediators such as high mobility group box‐1 protein (HMGB1), platelet‐derived growth factor (PDGF), phenylacetylglutamine (PAGln), lysophosphatidic acid (LPA), and citrullinated histone H3 (CH3) are upregulated, yet research on their specific roles remains limited. This evidence concerns the gene HMGB1 and Hyperglycemia.