NEFL and early-onset autosomal dominant Alzheimer disease: To address these gaps, this study leverages data from the Wake Forest Alzheimer's Disease Research Center (WF ADRC) community cohort to examine direct associations of ACEs with cognition, plasma ADRD biomarkers (glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL], amyloid beta 42/40 [Aβ42/40] ratio, and phosphorylated tau [p‐tau] 181), and cerebrovascular neuroimaging measures (white matter hyperintensity [WMH], diffusion tensor imaging metrics, and neurite orientation dispersion and density imaging [NODDI] indices).