Therefore, scholars have hypothesized that the reduction of the cells in FA patients impairs immune function, which affects the body's immune surveillance of cancer cells [131]; (3) FA patients may have increased susceptibility to the carcinogenic effects of human papillomavirus (HPV) [132]; (4) Recent genomic and exome sequencing results of FA SCCs patients indicate that these patients have low rates of HPV infection, but high frequencies of TP53 mutations. This evidence concerns the gene TP53 and Friedreich ataxia.