However the presence of anti-CCP2 antibodies was associated with increased concentations of antiCit H4 (14–34) (0.12 AU/ml to 0.38 AU/ml, p = 0.025) and antiCit H4(31–50) (0.14 AU/ml to 0.61 AU/ml, p < 0.001) in patients with fibrosis. The gene discussed is AGBL2; the disease is fibrosis.