CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; HbA1c, hemoglobine A1c; HDL, high-density-lipoprotein; HFpEF, heart failure with preserved ejection fraction; LV, left ventricle; NT-proBNP, N-terminal pro–B-type natriuretic peptide; TAPSE, tricuspid annular plane systolic excursion. The gene discussed is NPPB; the disease is heart failure.