In another study examining sensitization to cat allergens (Fel d 1, Fel d 2, Fel d 4, Fel d 7) within the adolescent population (n = 266) diagnosed with asthma, the levels of IgE to Fel d 4 (and Fel d 2–serum albumin) were found to be independently correlated with type-2 biomarkers as well as total IgE levels in young individuals affected by asthma (p = 0.009) [85]. This evidence concerns the gene IGHE and asthma.