Our pan-cancer analysis indicated a statistically significant expression of the PFKFB4 gene in various tumor types, including adrenal, acute myeloid leukemia (AML), bladder, breast, colon, esophageal, liver, lung squamous cell carcinoma, ovarian, pancreatic, rectal, renal clear cell carcinoma, renal chromophobe, renal papillary, skin, stomach, testicular, as well as in both endometrial and cervical uterine cancers. This evidence concerns the gene PFKFB4 and clear cell renal carcinoma.