We have previously reported that recombinant human MANF (rhMANF) protein can relieve carbon tetrachloride (CCl4)‐induced hepatic fibrosis[18] and lipopolysaccharide (LPS)‐triggered myocarditis,[23] and rhMANF can be used in mice without any species difference or immune response. The gene discussed is MANF; the disease is Hepatic fibrosis.