For cardiac function, echocardiography analysis showed the impaired cardiac functional indicators after TAC or Ang II administration, and MKO mice had more severe cardiac dysfunction compared to WT mice, including the weakened fractional shorting (FS)/ejection fraction (EF) and expanded left ventricular end‐diastolic diameter (LVEDD)/left ventricular end‐systolic dimension (LVEDS) (Figure 3d,e; Figure S3d,e, Supporting Information). The gene discussed is AGT; the disease is persistent truncus arteriosus.