find that Bisacurone inhibits BAX/Caspase‐3‐mediated apoptosis for alleviation of pressure overload‐induced cardiac hypertrophy.[64] Also, through high‐throughput microscopy imaging and mRNA abundance analysis in cardiac myocytes stimulated by 15 hypertrophic agonists, BAX is found to have a high correlation with Ang II‐induced MH, and Ang II‐dependent BAX increase enables an acceleration of pathological cardiac hypertrophy to result in cardiac fibrosis and dysfunction.[66] We proved the predicted protein interaction between MANF and BAX in this study, which was analogous to Ku70‐BAX binding. This evidence concerns the gene MANF and fibrosis.