HIF1A and breast cancer: In this context, Zheng et al. demonstrated that HIF1A-AS3, the authors called it “HIFAL” (HIF1α anti-sense lncRNA) promotes the association of s prolyl hydroxylase 3 (PHD3) to pyruvate kinase which represents an important step before transcriptional activation by Hif1α, which promotes glycolysis in several breast cancer cell lines38.