To investigate the impact of endogenous lactate on ccRCC, we further analyzed glycolysis and lactate transport-related proteins in the TCGA database of GEPIA and found that the expression level of the key glycolytic enzyme lactate dehydrogenase A (LDHA) in ccRCC is the highest among 33 types of human cancers (S1A). Here, HK1 is linked to nonpapillary renal cell carcinoma.