NKILA and neoplasm: NKILA inhibits NF-κB activity, preventing T cells from apoptosis and promoting their anti-tumor action.219 Additionally, lncRNAs like SNHG1 increase the presence of immunosuppressive cells, creating a more immunosuppressive environment that favors tumor survival.220 Moreover, lncRNAs play a significant role in mediating resistance to immunotherapy in breast cancer.