IL-10 enhances the immunosuppressive functions of these cells, which are abundant in the TME and contribute to the inhibition of CTLs and NK cells.331,332 In particular, TAMs often polarize into an M2-like phenotype in response to IL-10, characterized by the release of anti-inflammatory cytokines, growth factors, and enzymes that promote tumor growth, angiogenesis, and metastasis. Here, IL10 is linked to neoplasm.