YTHDF1 and neoplasm: Studies have demonstrated that YTHDF1 deficiency in dendritic cells (DCs) enhances the cross-priming of CD8+ T cells and improves the cross-presentation of tumor antigens in vivo.156 Recent research has illuminated that one mechanism driving the immune escape is the tumor-intrinsic factor YTHDF1, an m6A reader that regulates the translation of key lysosomal genes.