EZH2 and neoplasm: For example, the epigenetic repression of BRCA1 and BRCA2, genes implicated in DNA repair, has been associated with altered immune signaling in the TME.198 Additionally, the epigenetic alteration of CDKN2A can alter the TME, promoting immune evasion by recruiting regulatory Tregs and MDSCs, both of which suppress anti-tumor immunity.199 Moreover, the pivotal role of epigenetic regulation in T cell exhaustion within the TME has been underscored by recent findings that link the loss of histone methyltransferase EZH2 to mitochondrial dysfunction and impaired T cell function.