Targeting the circCCAR1/miR-127-5p/WTAP feedback loop could reverse this effect and enhance treatment efficacy.234 Similarly, circHMGB2 in NSCLC reshapes the TME by sponging miR-181a-5p and inactivating the type 1 interferon response, leading to immune suppression and PD-1 resistance. Here, PDCD1 is linked to non-small cell lung carcinoma.