CCL22 and neoplasm: Neutralizing CCL22 has been shown to significantly reduce Treg migration toward tumor tissues, underscoring its role in immune suppression.134,135 Similarly, CCL5 recruits diverse immune cells, including Tregs and MDSCs, and enhances their immunosuppressive functions, thereby promoting tumor progression and resistance to immune-mediated destruction.136,137 Recent studies have highlighted the critical role of macrophage-derived cytokines in immune evasion in cancer.