Key regulatory hubs identified from the map were validated through transcriptomic analysis, underscoring their relevance in BC metastasis.317 However, ALKBH5, an RNA m6A demethylase, has shown promise in suppressing TGF-β-induced EMT and metastasis in NSCLC by altering the stability and expression of critical components in the TGF-β/SMAD signaling pathway. Here, TGFB1 is linked to breast cancer.