Key regulatory hubs identified from the map were validated through transcriptomic analysis, underscoring their relevance in BC metastasis.317 However, ALKBH5, an RNA m6A demethylase, has shown promise in suppressing TGF-β-induced EMT and metastasis in NSCLC by altering the stability and expression of critical components in the TGF-β/SMAD signaling pathway. This evidence concerns the gene ALKBH5 and non-small cell lung carcinoma.