For example, TRAP1 (Tumor Necrosis Factor Receptor-Associated Protein 1) supports tumor growth in various cancers, where it is linked to poor survival outcomes.180 However, downregulation of TRAP1 in human ovarian cancer promotes invasion and epithelial–mesenchymal transition (EMT), processes that are closely associated with cancer aggressiveness and metastasis. Here, TRADD is linked to cancer.