PSMB8 and cervical carcinoma: Mutations in APM genes, such as those encoding proteasome subunits like LMP2, LMP7, and LMP10, can alter the repertoire of peptides generated and presented on MHC class I molecules.161 For example, genetic variations in the APM components, specifically the TAP2, LMP7, and ERAP1 genes, have been linked to a higher risk of cervical cancer.