The combined delivery of tumor-associated antigens with adjuvants like CpG ODN in nanoparticles has been demonstrated to induce strong CD8+ T cell proliferation and enhanced IFN-γ production, leading to prolonged overall survival in mouse tumor models.483 This co-delivery strategy can help overcome the immune tolerance often seen in tumors, where the immune system fails to recognize tumor-associated antigens as threats. Here, CD8A is linked to neoplasm.