In addition, it has been demonstrated that epilepsy-associated pathogenic GABRB3 Tyr302Cys (Y302C) variants can lead to loss-of-function receptors, and patients with this variant have severe developmental and epileptic encephalopathies (Absalom et al, 2022; Shi et al, 2019). Here, GABRB3 is linked to Epileptic encephalopathy.