CDKN2A and diabetes mellitus: We also observed mitochondrial swelling and altered cristae in kidneys of DM mice compared to those in kidneys of wild-type mice, whereas clearance of p16-positive senescent cells partial normalized mitochondrial morphology and cristae density in AP20187-treated DM INK-ATTAC lidneys as examined with transmission electron microscopy (TEM) (Fig. 5D).