CDKN2A and diabetes mellitus: In addition, clearance of p16-positive cells with the treatment of AP20187 decreased glomerular matrix deposition, renal tubular atrophy and renal interstitial fibrosis in DM INK-ATTAC mice as examined by hematoxylin and eosin (H&E), periodic acid-Schiff (PAS) and Masson blue staining (Fig. 3F).