As the Parkinson’s disease-associated VPS35(D620N) mutation leads to enhanced LRRK2 activation and target RAB phosphorylation130, it is tempting to speculate that Retromer’s role as a RAB regulatory hub may constitute a feedback controller in integrating lysosomal homoeostasis with endosomal retrieval sub-domain function. Here, AGFG1 is linked to Parkinson disease.