Estimating sex-stratified penetrance, the overall population penetrance8 of DSP pLoF was estimated as 0.08 (95%CI 0.05-0.12) for DCM, with sex-stratified estimated population penetrance in females of 0.11 (95%CI 0.06-0.20), and male penetrance of 0.02 (95% CI 0.01-0.07). The gene discussed is DSP; the disease is familial dilated cardiomyopathy.