Further metabolomic and transcriptomic analyses of LKB1- and KEAP1-mutant NSCLC cells revealed that SHMT2 expression was regulated by the NRF2-ATF4 signaling pathway, facilitating serine-glycine 1-carbon metabolism to meet increased demands for 1-carbon units and antioxidant defense (Lee et al., 2024a). This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.