In physiological conditions (Control in Fig. 6), a marked hypoalbuminemia was observed in the Pdpn-het KO mice compared with that in the wild-type (24.5 + 0.6 mg/mL in Pdpn-het mice vs 44.6 + 1.0 mg/mL in wild-type, 3 mice, each 2 samples p < 0.01 n = 6). This evidence concerns the gene PDPN and Hypoalbuminemia.